التفاصيل البيبلوغرافية
| العنوان: |
Alternative approaches to antifungal therapies. |
| المؤلفون: |
Mehra, Tarun, Köberle, Martin, Braunsdorf, Christina, Mailänder-Sanchez, Daniela, Borelli, Claudia, Schailer, Martin |
| المصدر: |
Experimental Dermatology; Oct2012, Vol. 21 Issue 10, p778-782, 5p, 2 Color Photographs, 1 Black and White Photograph, 1 Chart |
| مصطلحات موضوعية: |
ANTIFUNGAL agents, IMMUNOSUPPRESSIVE agents, HIV infections, PEPTIDES, PROTEINS |
| مستخلص: |
The expansive use of immunosuppressive medications in fields such as transplantational medicine and oncology, the higher frequency of invasive procedures in an ageing population and the HIV/AIDS pandemic have increased the frequency of systemic fungal infections. At the same time, increased resistance of pathogenic fungi to classical antifungal agents has led to sustained research efforts targeting alternative antifungal strategies. In this review, we focus on two promising approaches: cationic peptides and the targeting of fungal virulence factors. Cationic peptides are small, predominantly positively charged protein fragments that exert direct and indirect antifungal activities, one mechanism of action being the permeabilization of the fungal membrane. They include lysozyme, defensins and cathelicidins as well as novel synthetic peptides. Among fungal virulence factors, the targeting of candidal secreted aspartic proteinases seems to be a particularly promising approach. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
