التفاصيل البيبلوغرافية
| العنوان: |
Synthesis and In Vitro Cytotoxicity of Glycans-Capped Silver Nanoparticles. |
| المؤلفون: |
Dini, Luciana, Panzarini, Elisa, Serra, Antonio, Buccolieri, Alessandro, Manno, Daniela |
| المصدر: |
Nanomaterials & Nanotechnology; 2011, Vol. 1 Issue 1, p58-64, 7p |
| مصطلحات موضوعية: |
GLYCANS, SILVER nanoparticles, CHEMICAL synthesis, SUSTAINABLE chemistry, TRANSMISSION electron microscopy, CANCER cell proliferation |
| مستخلص: |
Silver nanostructures were successfully synthesized through a simple and "green" method using saccharides as reducing and capping agent. Transmission electron microscopy (TEM) and UV-Vis absorption were used to certify the quality of the silver nanoparticles obtained: firstly, size and dispersion. In this work Silver NanoParticles (AgNPs) cytotoxicity related to saccharides capping (Glucose and Glucose- Sucrose) was explored in human epitheloid cervix carcinoma cells (HeLa). The cells were incubated with increasing AgNPs number/cell and HeLa cells viability was monitored for a period of 48 h compared with the positive and negative controls. We observed that the toxicity increases with incubation time and with AgNPs number/cell. In particular, the different cytotoxic degree of the AgNPs, i.e. AgNP-G are more toxic than AgNP-GS, suggests that the cytotoxic effects are largely depended on the capping agent. The highest concentration of AgNP-G number/cell is able to induce extensive cell death of HeLa cells soon after 1 hr of incubation; conversely the lowest concentration of Ag NP-GS number/cell, surprisingly, is able to induce cell proliferation [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
