التفاصيل البيبلوغرافية
| العنوان: |
All-cause mortality in treated HIV-infected adults with CD4 ≥500/mm3 compared with the general population: evidence from a large European observational cohort collaboration†. |
| المؤلفون: |
Lewden, Charlotte, Bouteloup, Vincent, De Wit, Stéphane, Sabin, Caroline, Mocroft, Amanda, Wasmuth, Jan Christian, van Sighem, Ard, Kirk, Ole, Obel, Niels, Panos, George, Ghosn, Jade, Dabis, François, Mary-Krause, Murielle, Leport, Catherine, Perez-Hoyos, Santiago, Sobrino-Vegas, Paz, Stephan, Christoph, Castagna, Antonella, Antinori, Andrea, d'Arminio Monforte, Antonella |
| المصدر: |
International Journal of Epidemiology; Apr2012, Vol. 41 Issue 2, p433-445, 13p |
| مصطلحات موضوعية: |
HIV-positive youth, MORTALITY of AIDS patients, CD4 antigen, COHORT analysis, DATA analysis |
| مصطلحات جغرافية: |
EUROPE |
| مستخلص: |
Background Using data from a large European collaborative study, we aimed to identify the circumstances in which treated HIV-infected individuals will experience similar mortality rates to those of the general population.Methods Adults were eligible if they initiated combination anti-retroviral treatment (cART) between 1998 and 2008 and had one prior CD4 measurement within 6 months. Standardized mortality ratios (SMRs) and excess mortality rates compared with the general population were estimated using Poisson regression. Periods of follow-up were classified according to the current CD4 count.Results Of the 80 642 individuals, 70% were men, 16% were injecting drug users (IDUs), the median age was 37 years, median CD4 count 225/mm3 at cART initiation and median follow-up was 3.5 years. The overall mortality rate was 1.2/100 person-years (PY) (men: 1.3, women: 0.9), 4.2 times as high as that in the general population (SMR for men: 3.8, for women: 7.4). Among 35 316 individuals with a CD4 count ≥500/mm3, the mortality rate was 0.37/100 PY (SMR 1.5); mortality rates were similar to those of the general population in non-IDU men [SMR 0.9, 95% confidence interval (95% CI) 0.7–1.3] and, after 3 years, in women (SMR 1.1, 95% CI 0.7–1.7). Mortality rates in IDUs remained elevated, though a trend to decrease with longer durations with high CD4 count was seen. A prior AIDS diagnosis was associated with higher mortality.Conclusions Mortality patterns in most non-IDU HIV-infected individuals with high CD4 counts on cART are similar to those in the general population. The persistent role of a prior AIDS diagnosis underlines the importance of early diagnosis of HIV infection. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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