التفاصيل البيبلوغرافية
| العنوان: |
Genetic map of rat Chromosome 5 including the fatty ( fa) locus. |
| المؤلفون: |
Truett, G., Jacob, H., Miller, J., Drouin, G., Bahary, N., Smoller, J., Lander, E., Leibel, R. |
| المصدر: |
Mammalian Genome; Jan1995, Vol. 6 Issue 1, p25-30, 6p |
| مستخلص: |
Thirteen loci, including the obesity gene fatty ( fa), were incorporated into a linkage map of rat Chromosome (Chr) 5. These loci were mapped in obese ( fa/fa) progeny of a cross between BN×13M- fa/+ F animals. Obese rats were scored for BN and 13M alleles at four loci ( Ifna, D1S85h, C8b, and Lck1) by restriction fragment length polymorphisms and at eight additional loci ( Glut1, Sv4j2, R251, R735, R980, R252, R371, and R1138) by simple sequence length polymorphisms (SSLP). The resulting map spans 67.3 cM of Chr 5, presenting nine previously unmapped loci and one locus ( Lck1) previously assigned to Chr 5 by use of somatic cell hybrid lines. Seven of the eight SSLP loci are newly identified; the SSLP linkage group alone spans 56.8 cM. The order of the loci is Sv4j2-R251-R735-R980-R1138-Ifna-fa-D1S85h-C8b-(Glut1-R252-R371)-Lck1. One locus, D1S85h, was found to lie only 0.4 cM from fa, close enough to serve as a reliable marker for the prediction of phenotype from genotype, and will be useful also for studies on the development of obesity in the fatty rat. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
