التفاصيل البيبلوغرافية
| العنوان: |
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. |
| المؤلفون: |
Li, Meng, Zhao, Hong, Zhang, Xiaosong, Wood, Laura D., Anders, Robert A., Choti, Michael A., Pawlik, Timothy M., Daniel, Hubert D., Kannangai, Rajesh, Offerhaus, G Johan A., Velculescu, Victor E., Wang, Linfang, Zhou, Shibin, Vogelstein, Bert, Hruban, Ralph H, Papadopoulos, Nick, Cai, Jianqiang, Torbenson, Michael S., Kinzler, Kenneth W. |
| المصدر: |
Nature Genetics; Sep2011, Vol. 43 Issue 9, p828-829, 2p, 2 Charts |
| مصطلحات موضوعية: |
CHROMATIN, LIVER cancer, NUCLEOTIDE sequence, HEPATITIS C virus, GENETIC mutation, HEPATITIS B virus, GENETICS |
| مصطلحات جغرافية: |
UNITED States, EUROPE |
| مستخلص: |
Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
