التفاصيل البيبلوغرافية
| العنوان: |
Protective HIV-specific CD8+ T cells evade Treg cell suppression. |
| المؤلفون: |
Elahi, Shokrollah, Dinges, Warren L., Lejarcegui, Nicholas, Laing, Kerry J., Collier, Ann C., Koelle, David M., McElrath, M. Juliana, Horton, Helen |
| المصدر: |
Nature Medicine; Aug2011, Vol. 17 Issue 8, p989-995, 7p, 1 Diagram, 5 Graphs |
| مصطلحات موضوعية: |
T cell receptors, HLA histocompatibility antigens, HIV prevention, DISEASE progression, CELL death, KILLER cells |
| مستخلص: |
Specific human leukocyte antigens (HLAs), notably HLA-B*27 and HLA-B*57 allele groups, have long been associated with control of HIV-1. Although the majority of HIV-specific CD8+ T cells lose proliferative capacity during chronic infection, T cells restricted by HLA-B*27 or HLA-B*57 allele groups do not. Here we show that CD8+ T cells restricted by 'protective' HLA allele groups are not suppressed by Treg cells, whereas, within the same individual, T cells restricted by 'nonprotective' alleles are highly suppressed ex vivo. This differential sensitivity of HIV-specific CD8+ T cells to Treg cell-mediated suppression correlates with their expression of the inhibitory receptor T cell immunoglobulin domain and mucin domain 3 (Tim-3) after stimulation with their cognate epitopes. Furthermore, we show that HLA-B*27- and HLA-B*57-restricted effectors also evade Treg cell-mediated suppression by directly killing Treg cells they encounter in a granzyme B (GzmB)-dependent manner. This study uncovers a previously unknown explanation for why HLA-B*27 and HLA-B*57 allele groups are associated with delayed HIV-1 disease progression. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
