التفاصيل البيبلوغرافية
| العنوان: |
ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. |
| المؤلفون: |
Yong-Jun Chen, Meng Zhang, Dong-Min Yin, Lei Wen, Annie Ting, Pu Wang, Yi-Sheng Lu, Xin-Hong Zhu, Shu-Ji Li, Cui-Ying Wi, Xue-Ming Wang, Lai, Cary, Wen-Cheng Xiong, Lin Mei, Tian-Ming Gao |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 12/14/2010, Vol. 107 Issue 50, p21818-21823, 6p, 5 Graphs |
| مصطلحات موضوعية: |
AMINOBUTYRIC acid, AMINO acids, BUTYRIC acid, AMINO acid neurotransmitters, INTERNEURONS |
| مستخلص: |
Neuregulin 1 (NRG1) is a trophic factor that acts by stimulating ErbB receptor tyrosine kinases and has been implicated in neural development and synaptic plasticity. In this study, we investigated mechanisms of its suppression of longterm potentiation (LTP) in the hippocampus. We found that NRG1 did not alter glutamatergic transmission at SC-CAl synapses but increased the GABAA receptormediated synaptic currents in CAl pyramidal cells via a presynaptic mechanism. Inhibition of GABAA receptors blocked the suppressing effect of NRG1 on LTP and prevented ecto-ErbB4 from enhancing LIP, implicating a role of GABAergic transmission. To test this hypothesis further, we generated parvalbumin (PV)-Cre;ErbB4-/- mice in which ErbB4, an NRG1 receptor in the brain, is ablated specifically in PV-positive interneurons. NRG1 was no longer able to increase inhibitory postsynaptic currents and to suppress LTP in PV-Cre; ErbB4-/- hippocampus. Accordingly, contextual fear conditioning, a hippocampus-dependent test, was impaired in PV-Cre;ErbB4-/- mice. In contrast, ablation of ErbB4 in pyramidal neurons had no effect on NRG1 regulation of hippocampal LIP or contextual fear conditioning. These results demonstrate a critical role of ErbB4 in PV-positive interneurons but not in pyramidal neurons in synaptic plasticity and support a working model that NRG1 suppresses LIP by enhancing GABA release. Considering that NRG1 and ErbB4 are susceptibility genes of schizophrenia, these observations contribute to a better understanding of how abnormal NRG1/ErbB4 signaling may be involved in the pathogenesis of schizophrenia. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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