التفاصيل البيبلوغرافية
| العنوان: |
Effects of cytokines on long control region transcriptional activity in high-risk cutaneous human papillomavirus types 5 and 8. |
| المؤلفون: |
Donalisio, Manuela, Poli, Alice, Civra, Andrea, Landolfo, Santo, Lembo, David |
| المصدر: |
Archives of Virology; Apr2010, Vol. 155 Issue 4, p583-587, 5p, 1 Chart, 1 Graph |
| مصطلحات موضوعية: |
CYTOKINES, KERATINOCYTES, MEDICAL transcription, PAPILLOMAVIRUSES, SKIN cancer |
| مستخلص: |
Cytokines play an important role in the control of mucosal HPV transcription. However, there is little data available on cutaneous HPVs, which are associated with non-melanoma skin cancers. Here, we describe a cell-based assay exploiting HaCaT keratinocytes stably transfected with a reporter construct containing the long control region (LCR) regulatory sequence of gene transcription in HPV-5 and HPV-8. This novel assay has allowed the first systematic analysis of the effects of cytokines on HPV-5 and HPV-8 LCR activity and provides a valuable tool for the search for cutaneous HPV-gene expression inhibitors. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
