التفاصيل البيبلوغرافية
| العنوان: |
l-Arginine reverses cigarette-induced reduction of fractional exhaled nitric oxide in asthmatic smokers. |
| المؤلفون: |
Bruce, C. T., Zhao, D., Yates, D. H., Thomas, Paul S. |
| المصدر: |
Inflammopharmacology; Feb2010, Vol. 18 Issue 1, p9-16, 8p, 1 Chart, 2 Graphs |
| مصطلحات موضوعية: |
NITRIC oxide, ASTHMA, CIGARETTE smokers, CELLS, BLOOD flow, SMOKING |
| مستخلص: |
Complex mechanisms regulate nitric oxide (NO) synthesis. Cigarette smoking decreases fractional exhaled NO (FENO), while asthmatic inflammation increases FENO. To assess whether the smoking-induced decrease in FENO levels was reversible, asthmatic and non-asthmatic smokers inhaled the NO synthase (NOS) substrate, l-arginine. Aminoguanidine, a relatively selective Type II NOS inhibitor, was used also to assess the role of NOS subtypes in these changes of FENO. The study was a single-blinded, placebo-controlled, cross-over design in two parts. Part I: smoking asthmatic and non-asthmatic smoking subjects smoked one cigarette and then inhaled nebulised l-arginine or l-alanine (control). Spirometry, FENO, nasal NO (FNNO), FECO, were measured for 4 h. Part II: subjects inhaled nebulised aminoguanidine prior to an identical protocol as in Part I. Change in FENO was assessed as area under the curve (AUC). Part I: In asthmatic smokers, cigarette smoking followed by l-arginine caused a significant median increase in AUC of 29.2(17)% FENO change/hour ( p = 0.04), which did not occur in non-asthmatic smokers (baseline FENO 12.7(7.1–18) vs. 6.7(4–9.2) ppb, respectively). Part II: Aminoguanidine prior to smoking caused a significant fall in FENO in both asthmatic and non-asthmatic smokers. l-arginine showed significant reversal of this effect in both asthmatic and non-asthmatic subjects. In asthmatic smokers, l-arginine increases FENO after cigarette smoking but not in non-asthmatic smokers. The decrease in FENO after aminoguanidine and subsequent partial reversal by l-arginine in both groups, suggests that Type II NOS contributes to the FENO in both. [ABSTRACT FROM AUTHOR] |
|
Copyright of Inflammopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
