التفاصيل البيبلوغرافية
| العنوان: |
Mapping of quantitative trait loci affecting behaviour in swine. |
| المؤلفون: |
Reiner, G., Köhler, F., Berge, T., Fischer, R., Hübner-Weitz, K., Scholl, J., Willems, H. |
| المصدر: |
Animal Genetics; Aug2009, Vol. 40 Issue 4, p366-376, 11p, 2 Charts, 2 Graphs |
| مصطلحات موضوعية: |
ANIMAL genome mapping, SARCOCYSTOSIS, GENOTYPE-environment interaction, GENETIC polymorphisms, EXPERIMENTAL design, SWINE |
| مستخلص: |
Behavioural indices in vertebrates are under genetic control at least to some extent. In spite of significant behavioural problems in farm animals, information on the genetic background of behaviour is sparse. The aim of this study was to map QTL for behavioural indices in swine under healthy conditions and after infection with Sarcocystis miescheriana, as behaviour can be significantly influenced by disease . This well-described parasite model subsequently leads to acute (day 14 p.i.), subclinical (day 28 p.i.) and chronic disease (day 42 p.i.), allowing the study and comparison of the behaviour of pigs under four different states of health or disease. The study was based on a well-described Pietrain/Meishan F2 family that has recently allowed the detection of QTL for disease resistance. We have mapped six genome-wide significant and 24 chromosome-wide significant QTL for six behavioural indices in swine. Six of these QTL (i.e. 20% of total QTL) showed effects on behavioural traits of the healthy pigs (day 0). Some of them (QTL on SSC11 and 18) lost influence on behavioural activities during disease, while the effects of others (QTL on SSC5, SSC8) partly remained during the whole experiment, although with different effects on the distinct behavioural indices. The disease model has been of high relevance to detect effects of gene loci on behavioural indices. Considering the importance of segregating alleles and environmental conditions that allow the identification of the phenotype, we conclude that there are indeed QTL with interesting effects on behavioural indices in swine. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
