التفاصيل البيبلوغرافية
| العنوان: |
Effect of diet-induced energy deficit and body fat reduction on high-sensitive CRP and other inflammatory markers in obese subjects. |
| المؤلفون: |
Belza, A., Toubro, S., Stender, S., Astrup, A. |
| المصدر: |
International Journal of Obesity; Apr2009, Vol. 33 Issue 4, p456-464, 9p, 2 Charts, 2 Graphs |
| مصطلحات موضوعية: |
OBESITY, DIET, BIOMARKERS, C-reactive protein, FIBRINOGEN, HAPTOGLOBINS, OVERWEIGHT persons |
| مستخلص: |
Aims:To dissociate the possible differential effects of negative energy balance and reduction in body fat mass (FM) on inflammatory markers: C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), haptoglobin, transferrin and the adipokines leptin and adiponectin.Methods:Thirty-three obese subjects (BMI: 34.0±3.1 kg/m2, age: 43.0±10.5 years, mean±s.d., 16 men) participated in a 20-week controlled dietary intervention divided into four periods. Weight reduction was induced by an 8-week low energy diet (3.4 MJ d−1) (LED-1) followed by a 4-week weight maintenance program (M-1). Subsequently participants underwent an additional 4-week LED (4.2 MJ d−1) (LED-2) followed by a final 4-week weight maintenance diet (M-2). Blood samples and anthropometrics were assessed at baseline and after LED-1, M-1, LED-2 and M-2.Results:Body weight was significantly reduced by 13% (13.7±4.0 kg, P<0.0001) after LED-1. However, a reduction in high-sensitive CRP (hs-CRP) by 35% (−1.1 (95% CI: −2.5:0.2) mg l−1, P=0.02) only became apparent after LED-2, which produced an additional weight loss of 2.9 kg compared to baseline, and it was maintained after M-2 (−1.0 (−1.4:0.4) mg l−1, P=0.02). Also IL-6 was reduced by 21% (−0.6 (−2.4:0.2) ng l−1, P=0.02) after M-2. The reductions in hs-CRP and IL-6 were both associated with reduction in FM but not body weight. Haptoglobin, transferrin and leptin were significantly reduced after both LED-1 and LED-2, but increased during weight maintenance. Adiponectin was not significantly changed during the intervention.Conclusions:The results suggest that, whereas haptoglobin and transferrin respond more rapidly and are more susceptible to the acute change in energy balance, a reduction in hs-CRP and IL-6 seems to be achieved by a reduction in FM when a new steady state has been established.International Journal of Obesity (2009) 33, 456–464; doi:10.1038/ijo.2009.27; published online 24 February 2009 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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