التفاصيل البيبلوغرافية
| العنوان: |
Getting beneath the phenotype of anorexia nervosa: the search for viable endophenotypes and genotypes. (cover story) |
| المؤلفون: |
Treasure, Janet L. |
| المصدر: |
Canadian Journal of Psychiatry; Apr2007, Vol. 52 Issue 4, p212-219, 8p |
| مصطلحات موضوعية: |
ETIOLOGY of diseases, ANOREXIA nervosa treatment, THERAPEUTICS, EATING disorders, APPETITE disorders, BULIMIA, COMPULSIVE eating, PHENOTYPES, NEUROPSYCHOLOGY, BRAIN metabolism, ANOREXIA nervosa, CHROMOSOMES, COMPARATIVE studies, CONDITIONED response, FOOD habits, RESEARCH methodology, MEDICAL cooperation, RESEARCH, REWARD (Psychology), SEROTONIN, EVALUATION research, GENOTYPES |
| الملخص (بالإنجليزية): |
Treatment for anorexia nervosa has changed little from that described by Gull over a century ago. To focus merely on symptomatic relief from "not eating," as occurs with some forms of hospital care, is primitive. The evidence base to guide treatment is thin. Nevertheless, there is hope that better understanding of the causes and maintaining factors may translate into more sophisticated treatments. This review aims to look beyond the overt and startling "not eating" phenotype of anorexia nervosa and consider eating disorder endophenotypes. The first part of the review sets the eating behaviour, clinical, and psychopathological features into the context of what is now understood about the central control of appetite. The evidence base for a framework of potential eating disorder endophenotypes follows. Finally, ideas about how to translate endophenotypes into treatment are introduced. [ABSTRACT FROM AUTHOR] |
| Abstract (French): |
Le traitement de l'anorexie mentale a peu changé depuis la description qu'en a donnée Gull, il y a plus d'un siècle. Se concentrer seulement sur le soulagement symptomatique de «ne pas manger », comme cela se fait dans certaines formes de soins hospitaliers, est primitif. Les données probantes pour guider le traitement sont rares. Néanmoins, il y a de l'espoir qu'une meilleure comprehension des causes et des facteurs de maintien puisse se traduire par des traitements plus évolués. Cet article vise à aller plus loin que le phénotype «ne pas manger» évident et renversant de l'anorexie mentale, et à examiner les endophénotypes du trouble alimentaire. La première partie de l'article met le comportement alimentaire, les traits cliniques et psychopathologiques en contexte des connaissances actuelles stir le contrôle central de l'appétit. Les données probantes d'un cadre des endophénotypes possibles du trouble alimentaire suivent. Finalement, des idées sur la façon de traduire les endophénotypes en traitement sont présentées. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
