التفاصيل البيبلوغرافية
| العنوان: |
The role of a heat shock protein from V. cholerae 0139 in the gut immune response. |
| المؤلفون: |
Shibnath Mazumdar, Shalmoli Bhattacharyya, Sujata Ghosh, Siddhartha Majumdar |
| المصدر: |
Molecular & Cellular Biochemistry; Mar2007, Vol. 297 Issue 1/2, p9-19, 11p |
| مستخلص: |
Abstract??An immunodominant heat shock protein (Hsp 24) was purified fromVibrio cholerae O139at 42??C and used as an immunomodulator for studying the gut immune response. T cell clone and T cell line specific for the Hsp 24 were generated from the lymphocytes of lamina propria and intra-epithelial lymphocytes of mice orally infected withV. cholerae O139, respectively. The T cell clone was TCR ??, CD4and appeared to play an important role in the functioning of gut B-lymphocytes. The T cell line had heterogenous population of CD8 and CD4 cells, most of which were found to be TCR ??and a minor population was TCR ??. The lymphokine profile of T cell line showed IFN-? to be the most abundant lymphokine followed by IL-2 and IL-4. The possible involvement of alternative pathway of activation for T cell clone was also addressed in this study. The splenocytes showed an up-regulation of their CD2 receptor expression on stimulation with the Hsp-24. The pattern of lymphokines released by splenocytes stimulated with the Hsp-24 showed no particular cell type to be responsible for mounting immune response. Thus, there is involvement of both, mucosal and peripheral arm of the immune system. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
