التفاصيل البيبلوغرافية
| العنوان: |
Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. |
| المؤلفون: |
Gresko, Ekaterina, Roscic, Ana, Ritterhoff, Stefanie, Vichalkovski, Anton, del Sal, Giannino, Schmitz, M Lienhard |
| المصدر: |
EMBO Journal; 5/3/2006, Vol. 25 Issue 9, p1883-1894, 12p, 8 Graphs |
| مصطلحات موضوعية: |
P53 protein, DRUG therapy, GENE expression, APOPTOSIS, DNA-binding proteins, PHOSPHOPROTEINS, TUMOR suppressor proteins |
| مستخلص: |
The serine/threonine kinase HIPK2 phosphorylates the p53 protein at Ser 46, thus promoting p53-dependent gene expression and subsequent apoptosis. Here, we show that DNA damaging chemotherapeutic drugs cause degradation of endogenous HIPK2 dependent on the presence of a functional p53 protein. Early induced p53 allows caspase-mediated cleavage of HIPK2 following aspartic acids 916 and 977. The resulting C-terminally truncated HIPK2 forms show an enhanced induction of the p53 response and cell death, thus allowing the rapid amplification of the p53-dependent apoptotic program during the initiation phase of apoptosis by a regulatory feed-forward loop. The active HIPK2 fragments are further degraded during the execution and termination phase of apoptosis, thus ensuring the occurrence of HIPK2 signaling only during the early phases of apoptosis induction. [ABSTRACT FROM AUTHOR] |
|
Copyright of EMBO Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder