التفاصيل البيبلوغرافية
| العنوان: |
The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity. |
| المؤلفون: |
Chung Hun Ryu, Sae-Woong Kim, Kyu Hwa Lee, Joo Yong Lee, Hongtae Kim, Woon Kyu Lee, Byung Hyune Choi, Young Lim, Young Hoon Kim, Kweon-Haeng Lee, Tae-Kon Hwang, Tae-Youn Jun, Hyoung Kyun Rha |
| المصدر: |
Oncogene; 8/11/2005, Vol. 24 Issue 34, p5355-5364, 10p |
| مصطلحات موضوعية: |
TUMOR suppressor genes, TUMOR suppressor proteins, G proteins, NEUROFIBROMATOSIS, NEUROFIBROMA, PHAKOMATOSES |
| مستخلص: |
Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas. The NF2 gene encodes a protein called schwannomin or merlin, which is involved in regulating cell growth and proliferation through protein–protein interactions with various cellular proteins. In order to better understand the mechanism by which merlin exerts its function, yeast two-hybrid screening was performed and Ral guanine nucleotide dissociation stimulator (RalGDS), a downstream molecule of Ras, was identified as a merlin-binding protein. The direct interaction between merlin and RalGDS was confirmed both in vitro and in the NIH3T3 cells. The domain analyses revealed that the broad C-terminal region of merlin (aa 141–595) is necessary for the interaction with the C-terminal Ras-binding domain (RBD) of RalGDS. Functional studies showed that merlin inhibits the RalGDS-induced RalA activation, the colony formation and the cell migration in mammalian cells. These results suggest that merlin can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals.Oncogene (2005) 24, 5355–5364. doi:10.1038/sj.onc.1208633; published online 27 June 2005 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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