التفاصيل البيبلوغرافية
| العنوان: |
Global Distribution and Molecular Evolution of Bat Coronaviruses. |
| المؤلفون: |
El Sayes, Mohamed, Badra, Rebecca, Ali, Mohamed A., El-Shesheny, Rabeh, Kayali, Ghazi |
| المصدر: |
Zoonotic Diseases (2813-0227); Jun2024, Vol. 4 Issue 2, p146-161, 16p |
| مصطلحات موضوعية: |
MOLECULAR evolution, MIDDLE East respiratory syndrome, ZOONOSES, BAT diseases, BETACORONAVIRUS |
| مستخلص: |
Simple Summary: Bats are the second most diverse group of mammals in the world, with about 1400 different species, and they play an important role in both environmental and human health. Bats have been recognized as the natural reservoirs of a large variety of viruses. Viruses that spill over from bats can cause emerging new viruses which may lead to epidemics or pandemics. In recent years, several zoonotic diseases such as Severe Acute Respiratory Coronaviruses have been linked back to bats. Some bat species serve as carriers for multiple types of pathogens without getting sick themselves due to their unique immune system adaptations. In this review, we show the global distribution and molecular evolution of bat coronaviruses to understand the risk of spill-over into other hosts. Bat coronaviruses cause a wide range of illnesses in humans and animals. Bats are known to harbor a wide diversity of Alphacoronaviruses and Betacoronaviruses. Betacoronaviruses have been linked to Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and other diseases such as gastroenteritis, bronchiolitis, and pneumonia. In the last 20 years, three betacoronaviruses emerged and caused widespread outbreaks in humans, including two deadly betacoronavirus epidemics, SARS-CoV, with mortality rate of 10%, and MERS-CoV, with mortality rate of 34.7%, and SARS-CoV-2, which caused the COVID-19 pandemic, with mortality rate of 3.4%. Studies have shown that bats are the main natural reservoirs for these viruses or their ancestral viruses. Observed variations in bat coronavirus genomes indicate that these viruses may have a potential to transmit to other hosts in close contact with humans and subsequently transmit to humans. As of today, there are no reported cases of direct coronavirus transmission from bats to humans. One reason for this might be that intermediate hosts are required for the transmission of bat coronaviruses to humans. Further studies are needed to map the amino acids and genomic regions responsible for the interactions between the spike of coronavirus and its receptors. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
