التفاصيل البيبلوغرافية
| العنوان: |
Ratiometric fluorescence imaging of lysosomal NO in living cells and mice brains with Alzheimer's disease. |
| المؤلفون: |
Huang, Rui, Zhang, Ziwei, Shi, Zhen, Yang, Yumeng, Sun, Junyong, Gao, Feng |
| المصدر: |
Chemical Communications; 7/7/2024, Vol. 60 Issue 53, p6793-6796, 4p |
| مصطلحات موضوعية: |
ALZHEIMER'S disease, BLOOD-brain barrier, CONJUGATED polymers, FLUORESCENT polymers, MICE, FLUORESCENCE, ENDOTHELIAL cells |
| مستخلص: |
We report an integrated ratiometric lysosomal nitric oxide (NO) nanoprobe based on engineered semiconducting polymer dots (Pdots), LyNO-Pdots, which consist of a newly designed NO-responsive dye, a fluorescent conjugated polymer and two functional polymers. The developed probe LyNO-Pdots exhibit high specificity and stability, good photostability and favorable blood–brain barrier (BBB) penetration ability. The LyNO-Pdots are successfully applied to ratiometric imaging of lysosomal NO variations in brain-derived endothelial cells, brain tissues and mice brains with Alzheimer's disease (AD). The results demonstrate that the NO content in the brains of AD mice is considerably higher than that in normal mice. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
