التفاصيل البيبلوغرافية
| العنوان: |
Synthesis of 2‐Trifluoromethyl Pyridines through Multicomponent Kröhnke Reaction. |
| المؤلفون: |
Hong, Biqiong, Teng, Yun, Fang, Zheng, Wu, Wei, Weng, Zhiqiang |
| المصدر: |
European Journal of Organic Chemistry; 6/24/2024, Vol. 27 Issue 24, p1-5, 5p |
| مصطلحات موضوعية: |
AMMONIUM acetate, CHALCONES, ACETATES, AMMONIUM bromide, CHALCONE |
| مستخلص: |
A multicomponent Kröhnke reaction route toward 2‐trifluoromethyl pyridines from reaction of chalcones with easily available and stable 1‐(3,3,3‐trifluoro‐2‐oxopropyl)pyridin‐1‐ium bromide and ammonium acetate is reported. The reaction is found to be general with a range of substituted chalcones, and the applicability of the methodology in gram scale is demonstrated. Preliminary results suggest that this transformation is initiated by 1,4‐Michael addition, followed by inter‐ and intramolecular nucleophilic addition, and elimination. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
