التفاصيل البيبلوغرافية
| العنوان: |
Progression‐free survival is a weakly predictive surrogate end‐point for overall survival in follicular lymphoma: A systematic review and meta‐analysis. |
| المؤلفون: |
Milrod, Charles J., Kim, Kang Woo, Raker, Christina, Ollila, Thomas A., Olszewski, Adam J., Pelcovits, Ari |
| المصدر: |
British Journal of Haematology; Jun2024, Vol. 204 Issue 6, p2237-2241, 5p |
| مصطلحات موضوعية: |
FOLLICULAR lymphoma, OVERALL survival, PROGRESSION-free survival, DRUG approval, STATISTICAL correlation |
| مستخلص: |
Summary: Although progression‐free survival (PFS) is a commonly used surrogate end‐point for clinical trials of follicular lymphoma (FL), no analyses have evaluated the strength of surrogacy for PFS with overall survival (OS). A systematic review was performed and 20 studies (total participants, 10 724) met final inclusion criteria. PFS was weakly associated with OS (correlation coefficient; 0.383, p < 0.001). The coefficient of determination was 0.15 (95% CI: 0.002–0.35) suggesting 15% of OS variance could be explained by changes in PFS. This challenges the role for PFS as a surrogate end‐point for clinical trials and drug approvals. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
