التفاصيل البيبلوغرافية
| العنوان: |
Celebrating the Birthday of AMPA Receptor Nanodomains: Illuminating the Nanoscale Organization of Excitatory Synapses with 10 Nanocandles. |
| المؤلفون: |
Yuko Fukata, Masaki Fukata, MacGillavry, Harold D., Nair, Deepak, Hosy, Eric |
| المصدر: |
Journal of Neuroscience; 6/5/2024, Vol. 44 Issue 23, p1-18, 18p |
| مصطلحات موضوعية: |
AMPA receptors, SYNAPSES, HIGH resolution imaging, PRESYNAPTIC receptors, GLUTAMATE receptors, SCAFFOLD proteins, NEURAL transmission |
| مستخلص: |
A decade ago, in 2013, and over the course of 4 summer months, three separate observations were reported that each shed light independently on a new molecular organization that fundamentally reshaped our perception of excitatory synaptic transmission (Fukata et al., 2013; MacGillavry et al., 2013; Nair et al., 2013). This discovery unveiled an intricate arrangement of AMPA-type glutamate receptors and their principal scaffolding protein PSD-95, at synapses. This breakthrough was made possible, thanks to advanced super-resolution imaging techniques. It fundamentally changed our understanding of excitatory synaptic architecture and paved the way for a brand-new area of research. In this Progressions article, the primary investigators of the nanoscale organization of synapses have come together to chronicle the tale of their discovery. We recount the initial inquiry that prompted our research, the preceding studies that inspired our work, the technical obstacles that were encountered, and the breakthroughs that were made in the subsequent decade in the realm of nanoscale synaptic transmission. We review the new discoveries made possible by the democratization of super-resolution imaging techniques in the field of excitatory synaptic physiology and architecture, first by the extension to other glutamate receptors and to presynaptic proteins and then by the notion of trans-synaptic organization. After describing the organizational modifications occurring in various pathologies, we discuss briefly the latest technical developments made possible by super-resolution imaging and emerging concepts in synaptic physiology. [ABSTRACT FROM AUTHOR] |
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