التفاصيل البيبلوغرافية
| العنوان: |
The Use of D2 and Deuterated Water for the Introduction of a Label into 4-Aminobutanoic Acid. |
| المؤلفون: |
Shevchenko, V. P., Shevchenko, K. V., Andreeva, L. A., Nagaev, I. Yu., Myasoedov, N. F. |
| المصدر: |
Radiochemistry; Feb2024, Vol. 66 Issue 1, p97-104, 8p |
| مصطلحات موضوعية: |
DEUTERIUM, TRIFLUOROACETIC acid, GABA, CATALYTIC converters for automobiles, ACIDS, ISOTOPE exchange reactions |
| مستخلص: |
The efficiency of incorporating deuterium into 4-aminobutanoic acid (GABA) has been studied. The use of D2O at 200°C makes it possible to introduce into GABA an average of about 0.5 deuterium atoms, D2O with trifluoroacetic acid (1 : 1) at 250°C, an average 1.49 deuterium atoms with a yield of 15%. The solid-phase method permits introducing about 3 deuterium atoms per GABA molecule. During isotopic exchange with D2O, the use of a palladium–rhodium mixture pretreated with deuterium gas made it possible to produce [D]GABA with the deuterium content of 4.5–4.6 atoms. But in both cases, the yields of [D]GABA were low. Preparative amounts of [D]GABA were produced engaging additional supports. The best result was obtained when applying GABA to zeolite. Using D2O with 5% Pd/BaSO4–GABA–zeolite pretreated with deuterium gas, allows producing [D]GABA with an average content of 1.5–2.0 deuterium atoms and a yield of about 30%. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
