التفاصيل البيبلوغرافية
| العنوان: |
White blood cell count nadir to zero following intensive chemotherapy as a predictive factor for patients with acute myeloid leukemia. |
| المؤلفون: |
Fang, Jacob, Bosma, Grace, Aisner, Dara, McMahon, Christine, Amaya, Maria, Schwartz, Marc, Kaiser, Jeff, Abbott, Diana, Pan, Zenggang, Schowinsky, Jeffrey, Pang, Changlee, Gutman, Jonathan A., Pollyea, Daniel A. |
| المصدر: |
Leukemia & Lymphoma; Jun2024, Vol. 65 Issue 6, p800-807, 8p |
| مصطلحات موضوعية: |
LEUKOCYTE count, ACUTE myeloid leukemia, PROGRESSION-free survival, LEUCOCYTES, STEM cell transplantation |
| مستخلص: |
Predictors for response to intensive therapy in AML have focused on baseline factors: percent leukemic blasts in marrow, cytogenetic/molecular genetic abnormalities, and presence of secondary AML. Non-baseline dynamic factors, occurring after induction but before response, may be useful for decisions related to salvage chemotherapy. We hypothesized white blood cell (WBC) count nadir after induction may be a real time indicator of treatment efficacy. We also examined whether time to stem cell transplant (SCT) or baseline molecular genetic abnormalities are associated with a low nadir. Data showed WBC nadir = 0 was a negative predictor for response to intensive induction and was correlated with reduced overall survival and progression free survival. Patients with WBC nadir = 0 did not have a significantly longer time to SCT, and none of the mutations increased the likelihood of reaching WBC nadir = 0. WBC nadir may be a useful real-time monitor in AML patients receiving intensive induction chemotherapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
