التفاصيل البيبلوغرافية
| العنوان: |
Effects of resveratrol on the anthropometric indices and inflammatory markers: an umbrella meta-analysis. |
| المؤلفون: |
Molani-Gol, Roghayeh, Rafraf, Maryam |
| المصدر: |
European Journal of Nutrition; Jun2024, Vol. 63 Issue 4, p1023-1040, 18p |
| مصطلحات موضوعية: |
BODY mass index, RESEARCH funding, META-analysis, RANDOMIZED controlled trials, RESVERATROL, SYSTEMATIC reviews, MEDLINE, WAIST circumference, ANTHROPOMETRY, INFLAMMATION, ONLINE information services, CONFIDENCE intervals, BIOMARKERS, DIETARY supplements, C-reactive protein, TUMOR necrosis factors |
| مستخلص: |
Background: The evidence for resveratrol's anti-obesity and anti-inflammatory qualities is accumulating, though meta-analyses have reported mixed results. The current umbrella meta-analysis aimed to assess the present evidence and provide an accurate estimate of the overall effects of resveratrol on the anthropometric indices and inflammatory markers. Method: The Web of Science, PubMed, Scopus, and Google Scholar databases were searched till March 2023. The meta-analysis was performed utilizing a random-effects model. Moreover, the overall strength and quality of the evidence were assessed using the GRADE tool. Results: The results from 19 meta-analyses investigating 81 unique randomized controlled trials with 4088 participants revealed that resveratrol supplementation reduced the body mass index (ES = − 0.119, 95% CI (− 0.192, − 0.047), p = 0.001), waist circumference (ES = − 0.405, 95% CI [− 0.664, − 0.147], p = 0.002), serum levels of C-reactive protein (ES = − 0.390, 95% CI [− 0.474, − 0.306], p < 0.001), and tumor necrosis factor-α (ES = − 0.455, 95% CI [− 0.592, − 0.318], p < 0.001) in comparison to the control group. The effects of resveratrol on body weight and Interleukin-6 levels of participants were not significant. However, resveratrol administration significantly decreased body weight in trials with intervention duration ≥ 12 weeks [ES = − 0.160, 95% CI (− 0.268, − 0.052)] and supplement dosage ≥ 500 mg/day [ES = − 0.130, 95% CI (− 0.238, − 0.022)]. Conclusion: The findings suggest the beneficial effects of resveratrol supplementation on reducing general and central obesity, as well as decreasing some inflammatory markers. Nevertheless, further high-quality research is required to prove these achievements and also evaluate resveratrol's effects on other inflammatory markers. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
