التفاصيل البيبلوغرافية
| العنوان: |
Radiosurgical thalamotomy for essential tremor: state of the art, current challenges and future directions. |
| المؤلفون: |
Iorio-Morin, Christian, Mathieu, David, Franzini, Andrea, Hodaie, Mojgan, Villeneuve, Samuelle-Arianne, Hamel, Andréanne, Lozano, Andres M. |
| المصدر: |
Expert Review of Neurotherapeutics; Jun2024, Vol. 24 Issue 6, p597-605, 9p |
| مستخلص: |
Essential tremor (ET) is the most frequent movement disorder, affecting up to 5% of adults > 65 years old. In 30–50% of cases, optimal medical management provides insufficient tremor relief and surgical options are considered. Thalamotomy is a time-honored intervention, which can be performed using radiofrequency (RF), stereotactic radiosurgery (SRS), or magnetic resonance-guided focused ultrasounds (MRgFUS). While the latter has received considerable attention in the last decade, SRS has consistently been demonstrated as an effective and well-tolerated option. This review discusses the evidence on SRS thalamotomy for ET. Modern workflows and emerging techniques are detailed. Current outcomes are analyzed, with a specific focus on tremor reduction, complications and radiological evolution of the lesions. Challenges for the field are highlighted. SRS thalamotomy improves tremor in > 80% patients. The efficacy appears comparable to other modalities, including DBS, RF and MRgFUS. Side effects result mostly from idiosyncratic hyper-responses to radiation, which occur in up to 10% of treatments, are usually self-resolving, and are symptomatic in < 4% of patients. Future research should focus on accumulating more data on bilateral treatments, collecting long-term outcomes, refining targeting, and improving lesion consistency. [ABSTRACT FROM AUTHOR] |
|
Copyright of Expert Review of Neurotherapeutics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
