التفاصيل البيبلوغرافية
| العنوان: |
Spiroplasma infection as a cause of severe congenital keratouveitis, cataract and glaucoma. |
| المؤلفون: |
Van Haecke, Helena, Roels, Dimitri, Nerinckx, Fanny, Schaballie, Heidi, Schelstraete, Petra, Vandekerckhove, Linos, Van Cleemput, Jolien, Van den Broeck, Wim, Couck, Liesbeth, Hamerlinck, Hannelore, Vandendriessche, Stien, Boelens, Jerina, Joniau, Inge |
| المصدر: |
BMC Ophthalmology; 5/21/2024, Vol. 24 Issue 1, p1-5, 5p |
| مصطلحات موضوعية: |
IRIDOCYCLITIS, CRYSTALLINE lens, CATARACT, CONGENITAL disorders, ANGLE-closure glaucoma, CONSCIOUSNESS raising |
| مستخلص: |
Background: Only seven cases of ocular Spiroplasma infection have been reported to date, all presenting as congenital cataracts with concomitant intraocular inflammation. We describe the first case of Spiroplasma infection initially presenting as a corneal infiltrate. Case presentation: A 1-month-old girl was referred for a corneal infiltrate in the left eye. She presented in our hospital with unilateral keratouveitis. Examination showed a stromal corneal infiltrate and dense white keratic precipitates in the left eye. Herpetic keratouveitis was suspected and intravenous acyclovir therapy was initiated. Two weeks later, the inflammation in the left eye persisted and was also noticed in the right eye. Acute angle-closure glaucoma and a cataract with dilated iris vessels extending onto the anterior lens capsule developed in the left eye. The inflammation resolved after treatment with azithromycin. Iridectomy, synechiolysis and lensectomy were performed. Bacterial metagenomic sequencing (16 S rRNA) and transmission electron microscopy revealed Spiroplasma ixodetis species in lens aspirates and biopsy. Consequently, a diagnosis of bilateral Spiroplasma uveitis was made. Conclusions: In cases of congenital cataract with concomitant intraocular inflammation, Spiroplasma infection should be considered. The purpose of this case report is to raise awareness of congenital Spiroplasma infection as a cause of severe keratouveitis, cataract and angle-closure glaucoma in newborns. Performing molecular testing on lens aspirates is essential to confirm diagnosis. Systemic macrolides are suggested as the mainstay of treatment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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