التفاصيل البيبلوغرافية
| العنوان: |
Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study. |
| المؤلفون: |
Chen, Zhengwei, Liu, Yueji, Lin, Cunxin, Li, Zhining, Shan, Junjun, Duan, Zuowei, Rong, Liangqun, Wei, Xiue, Xiao, Lijie, Liu, Haiyan |
| المصدر: |
Journal of Headache & Pain; 5/21/2024, Vol. 25 Issue 1, p1-13, 13p |
| مصطلحات موضوعية: |
EMOTION regulation, FUNCTIONAL connectivity, DISEASE duration, RESEARCH funding, BRAIN, PREFRONTAL cortex, MAGNETIC resonance imaging, THALAMUS, TEMPORAL lobe, VESTIBULAR apparatus diseases, LIMBIC system, CEREBRAL circulation, FREE radicals, COMPARATIVE studies, PARIETAL lobe, MIGRAINE, MEDICAL practice |
| مستخلص: |
Background: Prior neuroimaging studies on vestibular migraine (VM) have extensively certified the functional and structural alterations in multiple brain regions and networks. However, few studies have assessed the cerebral blood flow (CBF) in VM patients using arterial spin labeling (ASL). The present study aimed to investigate CBF and functional connectivity (FC) alterations in VM patients during interictal periods. Methods: We evaluated 52 VM patients and 46 healthy controls (HC) who received resting-state pseudo-continuous ASL and functional magnetic resonance imaging (fMRI) scanning. Comparisons of voxel-based CBF and seed-based FC were performed between the two groups. Brain regions showed significant group differences in CBF analyses were chosen as seeds in FC analyses. Additionally, the associations between abnormal imaging results and clinical features were explored. Results: Compared with HC, VM patients showed higher normalized CBF in the right precentral gyrus (PreCG), left postcentral gyrus (PostCG), left superior frontal gyrus and bilateral insular (p < 0.05, FDR corrected). Furthermore, VM patients exhibited increased FC between the right PreCG and areas of the left PostCG, left cuneus and right lingual gyrus (p < 0.05, FDR corrected). In addition, we observed decreased FC between the left insular and regions of the left thalamus and right anterior cingulate cortex, as well as increased FC between the left insular and right fusiform gyrus in VM patients (p < 0.05, FDR corrected). Moreover, these variations in brain perfusion and FC were significantly correlated with multiple clinical features including frequency of migraine symptoms, frequency of vestibular symptoms and disease duration of VM (all p < 0.05). Conclusions: Patients with VM during interictal period showed hyperperfusion and abnormal resting-state FC in brain regions potentially contributed to disrupted multi-sensory and autonomic processing, as well as impaired ocular motor control, pain modulation and emotional regulation. Our study provided novel insights into the complex neuropathology of VM from a CBF perspective. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Headache & Pain is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder