التفاصيل البيبلوغرافية
| العنوان: |
Dereplication of polar extracts from Croton antisyphiliticus Mart. roots and its anti-inflammatory and antinociceptive potential. |
| المؤلفون: |
Simão, Jorge Luiz Souza, Prado, Stephanie Vilela, Pereira, Alana Kelyene, Alexandre, Gerso Pereira, Pires Gomide, Núbia Alves Mariano Teixeira, Matos da Silva, Marcia, Almeida, Dionys de Souza, Martins, Aline Nazareth, Bueno da Silva, Daiany Priscilla, Costa, Elson Alves da, Pasqualotto Severino, Vanessa Gisele |
| المصدر: |
Natural Product Research; Jun2024, Vol. 38 Issue 12, p2118-2122, 5p |
| مصطلحات موضوعية: |
PLANT extracts, CROTON (Genus), LABORATORY mice, MYELOPEROXIDASE, MASS spectrometers, ANTIARTHRITIC agents, DEXAMETHASONE |
| مستخلص: |
Croton antisyphiliticus Mart. is a plant popularly used in folk medicine by traditional communities from Brazilian savannah to treat general inflammation. According to ethnopharmacological data, this specie can be considered a source of biologically active molecules for the development of new drugs. Thereby, this study reports the results of the dereplication approach of C. antisyphiliticus roots extracts and the in vivo evaluation of its potential antinociceptive and anti-inflammatory in albino Swiss mice. Based on HPLC coupled to Q-Exactive Orbitrap Mass Spectrometer and using GNPS, a total of thirteen polyphenolic compounds were noticed, including four compounds that have been reported for the first time in the genus Croton. Ethanolic and aqueous roots extracts demonstrated a dose-dependent inhibition for the number of writes, reduced pain induced by formalin and hyperalgesia induced by carrageenan. These extracts also reduced paw edema, cell migration, and myeloperoxidase activity, with effects similar to indomethacin and dexamethasone drugs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
