التفاصيل البيبلوغرافية
| العنوان: |
PREVALENCE OF HIGH-RISK HUMAN PAPILLOMAVIRUS (HR-HPV) GENOTYPES IN CLINICAL SAMPLES OF SEXUALLY ACTIVE WOMEN: A HOSPITAL BASED STUDY. |
| المؤلفون: |
Yadav, Amod Kumar, Kumar, Rohit, Gupta, Tanuj, Gill, Paramjeet Singh, Kumari, Reenu |
| المصدر: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2024, Vol. 15 Issue 4, p1275-1288, 14p |
| مصطلحات موضوعية: |
HUMAN papillomavirus, SEXUALLY transmitted diseases, CARCINOGENS, PAPILLOMAVIRUS diseases, GENITAL warts, GENOTYPES, AUJESZKY'S disease virus |
| مصطلحات جغرافية: |
INDIA |
| الشركة/الكيان: |
INTERNATIONAL Agency for Research on Cancer |
| مستخلص: |
Background: Human papillomavirus (HPV) is the most common sexually transmitted infection in the world and is classified as a carcinogenic infectious agent by the International Agency for Research on Cancer. However, only some HPV strains are oncogenic. The oncogenicity of the virus is primarily dependent on the continuous expression and activity of the viral proteins E6 and E7. HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 73 and 82 are considered highrisk genotypes, Of the high-risk HPV types, HPV16 is the most frequently detected at the population level, and it is by far the predominant type causing invasive cervical cancer worldwide (~60%), followed by HPV18 (~15%) [23]. HPV serotypes 16 and 18 together cause up to 70% of invasive cervical cancer worldwide. Cervical cancer ranks as the 2nd leading cause of female cancer in India. This is the most frequently occurring type of cancer in women aged 15 to 44 years after breast cancer. Objective: To study the qualitative detection of Human papillomavirus (HPV) DNA in clinical samples and genotyping of 14 high-risk (HR-HPV). Material and Method: The present study has been done on the women attending Obstetrics and Gynaecology OPD in the regional tertiary care hospital with symptomatic gynaecological problems due to the presence of Human Papillomavirus infections. Hence in the present study, we have used Real-Time PCR (BIO-RAD, CFX96 Real-Time System) for HPV DNA testing by using "TRUPCR® HPV High Risk Genotyping Plus Kit" as per manufacturer's instructions. Results: The prevalence of HPV is 23.24% in the present study. In which HPV16 accounts for 62.79% of the total prevalence followed by HPV58 (9.3%), HPV31, HPV33, and HPV39 each having prevalence of 6.97%. Next in descending order were HPV35, HPV51, and HPV68 having a prevalence of 4.65%, 4.65% and 2.32% respectively. Conclusion: It has been observed that there is a high prevalence of HPV16 followed by HPV58, 31, 33, 35 and 39. Our study further recommends studying the prevalence and genotyping variations in the locality before providing a vaccine in the vaccination schedule as an effective prophylactic means. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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