التفاصيل البيبلوغرافية
| العنوان: |
Cyclometalated and NNN Terpyridine Ruthenium Photocatalysts and Their Cytotoxic Activity. |
| المؤلفون: |
Ballico, Maurizio, Alessi, Dario, Aneggi, Eleonora, Busato, Marta, Zuccaccia, Daniele, Allegri, Lorenzo, Damante, Giuseppe, Jandl, Christian, Baratta, Walter |
| المصدر: |
Molecules; May2024, Vol. 29 Issue 9, p2146, 17p |
| مصطلحات موضوعية: |
PHOTOCATALYSTS, ANAPLASTIC thyroid cancer, RUTHENIUM, TRANSFER hydrogenation, THYROGLOBULIN, ACETATE derivatives, ACETATES |
| مستخلص: |
The cyclometalated terpyridine complexes [Ru(η2-OAc)(NC-tpy)(PP)] (PP = dppb 1, (R,R)-Skewphos 4, (S,S)-Skewphos 5) are easily obtained from the acetate derivatives [Ru(η2-OAc)2(PP)] (PP = dppb, (R,R)-Skewphos 2, (S,S)-Skewphos 3) and tpy in methanol by elimination of AcOH. The precursors 2, 3 are prepared from [Ru(η2-OAc)2(PPh3)2] and Skewphos in cyclohexane. Conversely, the NNN complexes [Ru(η1-OAc)(NNN-tpy)(PP)]OAc (PP = (R,R)-Skewphos 6, (S,S)-Skewphos 7) are synthesized in a one pot reaction from [Ru(η2-OAc)2(PPh3)2], PP and tpy in methanol. The neutral NC-tpy 1, 4, 5 and cationic NNN-tpy 6, 7 complexes catalyze the transfer hydrogenation of acetophenone (S/C = 1000) in 2-propanol with NaOiPr under light irradiation at 30 °C. Formation of (S)-1-phenylethanol has been observed with 4, 6 in a MeOH/iPrOH mixture, whereas the R-enantiomer is obtained with 5, 7 (50–52% ee). The tpy complexes show cytotoxic activity against the anaplastic thyroid cancer 8505C and SW1736 cell lines (ED50 = 0.31–8.53 µM), with the cationic 7 displaying an ED50 of 0.31 µM, four times lower compared to the enantiomer 6. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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