التفاصيل البيبلوغرافية
| العنوان: |
Kdm7a expression is spatiotemporally regulated in developing Xenopus laevis embryos, and its overexpression influences late retinal development. |
| المؤلفون: |
Martini, Davide, Digregorio, Matteo, Voto, Ilaria Anna Pia, Morabito, Giuseppe, Degl'Innocenti, Andrea, Giudetti, Guido, Giannaccini, Martina, Andreazzoli, Massimiliano |
| المصدر: |
Developmental Dynamics; May2024, Vol. 253 Issue 5, p508-518, 11p |
| مصطلحات موضوعية: |
GENE expression, XENOPUS laevis, GENETIC overexpression, HISTONE demethylases, CENTRAL nervous system |
| مستخلص: |
Background: Post‐translational histone modifications are among the most common epigenetic modifications that orchestrate gene expression, playing a pivotal role during embryonic development and in various pathological conditions. Among histone lysine demethylases, KDM7A, also known as KIAA1718 or JHDM1D, catalyzes the demethylation of H3K9me1/2 and H3K27me1/2, leading to transcriptional regulation. Previous data suggest that KDM7A plays a central role in several biological processes, including cell proliferation, commitment, differentiation, apoptosis, and maintenance. However, information on the expression pattern of KDM7A in whole organisms is limited, and its functional role is still unclear. Results: In Xenopus development, kdm7a is expressed early, undergoing spatiotemporal regulation in various organs and tissues, including the central nervous system and the eye. Focusing on retinal development, we found that kdm7a overexpression does not affect the expression of genes critically involved in early neural development and eye‐field specification, whereas unbalances the distribution of neural cell subtypes in the mature retina by disfavoring the development of ganglion cells while promoting that of horizontal cells. Conclusions: Kdm7a is dynamically expressed during embryonic development, and its overexpression influences late retinal development, suggesting a potential involvement in the molecular machinery regulating the spatiotemporally ordered generation of retinal neuronal subtypes. Key Findings: Histone methylation are among the most common epigenetic modifications that orchestrate gene expression.Although the histone demethylases kdm7a has been involved in various biological processes, data about its expression pattern and functional role during embryogenesis are still limited.Herein, we analyze the spatio‐temporal expression pattern of kdm7a in Xenopus laevis development and found that kdm7a overexpression specifically affects retinogenesis by disfavouring the development of ganglion cells while promoting that of horizontal cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
