التفاصيل البيبلوغرافية
| العنوان: |
Models of Trigeminal Activation: Is There an Animal Model of Migraine? |
| المؤلفون: |
Spekker, Eleonóra, Fejes-Szabó, Annamária, Nagy-Grócz, Gábor |
| المصدر: |
Brain Sciences (2076-3425); Apr2024, Vol. 14 Issue 4, p317, 19p |
| مصطلحات موضوعية: |
MIGRAINE, ANIMAL models in research, LABORATORY animals, SPREADING cortical depression, PRIMARY headache disorders, HUMAN ecology, DURA mater, MIGRAINE aura |
| مستخلص: |
Migraine, recognized as a severe headache disorder, is widely prevalent, significantly impacting the quality of life for those affected. This article aims to provide a comprehensive review of the application of animal model technologies in unraveling the pathomechanism of migraine and developing more effective therapies. It introduces a variety of animal experimental models used in migraine research, emphasizing their versatility and importance in simulating various aspects of the condition. It details the benefits arising from the utilization of these models, emphasizing their role in elucidating pain mechanisms, clarifying trigeminal activation, as well as replicating migraine symptoms and histological changes. In addition, the article consciously acknowledges the inherent limitations and challenges associated with the application of animal experimental models. Recognizing these constraints is a fundamental step toward fine-tuning and optimizing the models for a more accurate reflection of and translatability to the human environment. Overall, a detailed and comprehensive understanding of migraine animal models is crucial for navigating the complexity of the disease. These findings not only provide a deeper insight into the multifaceted nature of migraine but also serve as a foundation for developing effective therapeutic strategies that specifically address the unique challenges arising from migraine pathology. [ABSTRACT FROM AUTHOR] |
|
Copyright of Brain Sciences (2076-3425) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder