دورية أكاديمية

Mortality and Autopsy Findings in Patients with Pyoderma Gangrenosum: A Multi-Institutional Series.

التفاصيل البيبلوغرافية
العنوان: Mortality and Autopsy Findings in Patients with Pyoderma Gangrenosum: A Multi-Institutional Series.
المؤلفون: Shakshouk, Hadir, deCampos-Stairiker, Mallory, Kody, Shannon, Stenzel, Peter, Xia, Eric, Mostaghimi, Arash, Wu, Bicong, Shinohara, Michi M., Marzano, Angelo V., Polly, Samantha, Fernandez, Anthony P., Ortega-Loayza, Alex G.
المصدر: Dermatology (10188665); 2024, Vol. 240 Issue 2, p352-356, 5p
مصطلحات موضوعية: AUTOPSY, INFLAMMATORY bowel diseases, CAUSES of death, ELECTRONIC health records, MORTALITY, PYODERMA gangrenosum
مستخلص: Introduction: Pyoderma gangrenosum (PG) is a rare ulcerative skin condition with an increased risk of mortality compared to the general population. The causes of this increased risk are not well understood. Misdiagnosis is common in PG, and many studies are limited by the inclusion of misdiagnosed cases. The goal of this study was to review autopsy findings, identify causes of death, and identify factors that may worsen outcomes among deceased patients confirmed to have PG. Methods: Data was retrospectively reviewed from the electronic medical records at five academic hospitals. A search was conducted for deceased patients with a diagnosis of PG who had an autopsy performed between 2010 and 2020. We report a descriptive analysis of 11 patients and their clinical characteristics, causes of death, and autopsy findings. Results: The average age of death was 62.9 years. Seven patients had at least one underlying condition known to be associated with PG including inflammatory bowel disease, inflammatory arthritis, or a hematologic disorder. The most common cause of death was infection (n = 6, 54.5%), followed by pulmonary embolism (n = 3, 27.3%), and myelodysplastic syndrome (n = 2, 18.2%). Six patients (54.5%) were taking systemic steroids at the time of death. Conclusion: The development of PG may shorten life expectancy among those with underlying conditions associated with PG, and common treatments for PG may contribute to the risk of fatal complications. Awareness of the risk of infection, thrombosis, and malignancy among those with PG is necessary for proper management. Further research is needed to explore the relationship between PG and thromboembolism. [ABSTRACT FROM AUTHOR]
Copyright of Dermatology (10188665) is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
قاعدة البيانات: Complementary Index
الوصف
تدمد:10188665
DOI:10.1159/000536145