التفاصيل البيبلوغرافية
| العنوان: |
Clinical research progress of ridaforolimus (AP23573, MK8668) over the past decade: a systemic review. |
| المؤلفون: |
Lumin Wang, Qining Qiu, Dawei Yang, Chang Cao, Yanqin Lu, Yulan Zeng, Weiwen Jiang, Yun Shen, Yanrong Ye |
| المصدر: |
Frontiers in Pharmacology; 2024, p1-8, 8p |
| مصطلحات موضوعية: |
MEDICAL research, THERAPEUTICS, RENAL cell carcinoma, MTOR inhibitors, ENDOMETRIAL cancer |
| مستخلص: |
Rapamycin, an established mTOR inhibitor in clinical practice, is widely recognized for its therapeutic efficacy. Ridaforolimus, a non-prodrug rapalog, offers improved aqueous solubility, stability, and affinity compared to rapamycin. In recent years, there has been a surge in clinical trials involving ridaforolimus. We searched PubMed for ridaforolimus over the past decade and selected clinical trials of ridaforolimus to make a summary of the research progress of ridaforolimus in clinical trials. The majority of these trials explored the application of ridaforolimus in treating various tumors, including endometrial cancer, ovarian cancer, prostate cancer, breast cancer, renal cell carcinoma, and other solid tumors. These trials employed diverse drug combinations, incorporating agents such as ponatinib, bicalutamide, dalotuzumab, MK-2206, MK-0752, and taxanes. The outcomes of these trials unveiled the diverse potential applications of ridaforolimus in disease treatment. Our review encompassed analyses of signaling pathways, ridaforolimus as a single therapeutic agent, its compatibility in combination with other drugs, and an assessment of adverse events (AEs). We conclude by recommending further research to advance our understanding of ridaforolimus's clinical applications. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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