التفاصيل البيبلوغرافية
| العنوان: |
Researchers from Indiana University School of Medicine Report on Findings in Neurofibroma (Spatial Gene-expression Profiling Unveils Immuno-oncogenic Programs of Nf1-associated Peripheral Nerve Sheath Tumor Progression). |
| المصدر: |
Genomics & Genetics Weekly; 4/19/2024, p1622-1622, 1p |
| مصطلحات موضوعية: |
PERIPHERAL nerve tumors, NEUROFIBROMA, SCHWANNOMAS, CANCER invasiveness, NEUROLOGICAL disorders, RESEARCH personnel |
| مستخلص: |
Researchers from Indiana University School of Medicine have conducted a study on neurofibroma, a type of peripheral nerve sheath tumor associated with neurofibromatosis type 1 (NF1). The study aimed to identify the molecular features associated with the evolution and transformation of neurofibroma into malignant peripheral nerve sheath tumor (MPNST). The researchers found that atypical neurofibroma (ANF) precursor lesions exhibit enhanced signatures of antigen presentation and immune response, which are suppressed during malignant transformation. They also identified deregulated survival and mitotic fidelity pathways in MPNST. These findings may serve as molecular diagnostic tools to identify neurofibromas at high risk of malignant transformation, facilitating personalized care. [Extracted from the article] |
|
Copyright of Genomics & Genetics Weekly is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
