دورية أكاديمية

An Unusual Presentation of Midline Lethal Granuloma.

التفاصيل البيبلوغرافية
العنوان: An Unusual Presentation of Midline Lethal Granuloma.
المؤلفون: Chin, Ein Wan, Saniasiaya, Jeyasakthy, Hitam, Shahrul, Hassan, Eyzawiah, Kah Wai, Ngan
المصدر: Indian Journal of Otolaryngology & Head & Neck Surgery; Apr2024, Vol. 76 Issue 2, p2137-2140, 4p
مصطلحات موضوعية: GRANULOMA, T-cell lymphoma, EXTRANODAL NK-T-cell lymphoma, NON-Hodgkin's lymphoma, TUBERCULOSIS, SEZARY syndrome
مستخلص: Extranodal natural killer T-cell lymphoma, nasal type (ENKTCL), is a rare form of non-Hodgkin lymphoma that is strongly related to Epstein-Barr Virus (EBV) infection and commonly presents as "midline lethal granuloma." Herein, we report a middle-aged lady who presented with a two-week history of fever, sore throat and constitutional symptoms. Intraoral examination revealed a lacerated soft palate with an ulcerated uvula. A diagnosis of ENKTCL was confirmed through deep biopsies under general anaesthesia supplemented with a positive serum EBV genome. Unfortunately, she succumbed due to disease progression with left frontal brain metastasis with concurrent pulmonary tuberculosis before treatment was completed. The recommended treatment is multimodality with L-asparaginase-containing regimes chemotherapy in an advanced stage, relapsed, or refractory ENKTCL for better outcomes. The quantification of circulating plasma EBV deoxyribonucleic acid (DNA) is helpful as the baseline of tumour load and a biomarker for monitoring treatment response and prognostication. We advocate repeated and deeper core tissue biopsies. [ABSTRACT FROM AUTHOR]
Copyright of Indian Journal of Otolaryngology & Head & Neck Surgery is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
قاعدة البيانات: Complementary Index
الوصف
تدمد:22313796
DOI:10.1007/s12070-023-04466-x