التفاصيل البيبلوغرافية
| العنوان: |
Timeframe Analysis of Novel Synthetic Cannabinoids Effects: A Study on Behavioral Response and Endogenous Cannabinoids Disruption. |
| المؤلفون: |
Pineda Garcia, Jorge Carlos, Li, Ren-Shi, Kikura-Hanajiri, Ruri, Tanaka, Yoshitaka, Ishii, Yuji |
| المصدر: |
International Journal of Molecular Sciences; Mar2024, Vol. 25 Issue 6, p3083, 16p |
| مصطلحات موضوعية: |
SYNTHETIC marijuana, BRAIN-derived neurotrophic factor, CANNABINOID receptors, CANNABINOIDS, TIME measurements, TROPANES, MOTOR ability, MEMORY disorders |
| مصطلحات جغرافية: |
TRIPOLI (Libya) |
| مستخلص: |
This study investigates the impact of SCs consumption by assessing the effects of three novel synthetic cannabinoids (SCs); MDMB-CHMINACA, 5F-ADB-PINACA, and APICA post-drug treatment. SCs are known for their rapid onset (<1 min) and prolonged duration (≥5 h). Therefore, this research aimed to assess behavioral responses and their correlation with endocannabinoids (ECs) accumulation in the hippocampus, and EC's metabolic enzymes alteration at different timeframes (1-3-5-h) following drug administration. Different extents of locomotive disruption and sustained anxiety-like symptoms were observed throughout all-encompassing timeframes of drug administration. Notably, MDMB-CHMINACA induced significant memory impairment at 1 and 3 h. Elevated levels of anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) were detected 1 h post-MDMB-CHMINACA and 5F-ADB-PINACA administration. Reduced mRNA expression levels of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) (AEA and 2-AG degrading enzymes, respectively), and brain-derived neurotrophic factor (BDNF) occurred at 1 h, with FAAH levels remaining reduced at 3 h. These findings suggest a connection between increased EC content and decreased BDNF expression following SC exposure. Cognitive disruption, particularly motor coordination decline and progressive loss manifested in a time-dependent manner across all the analyzed SCs. Our study highlights the importance of adopting a temporal framework when assessing the effects of SCs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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