التفاصيل البيبلوغرافية
| العنوان: |
Trabecular Bone Score as a More Sensitive Tool to Evaluate Bone Involvement in MEN1-related Primary Hyperparathyroidism. |
| المؤلفون: |
Song, An, Chen, Rong, Guan, Wenmin, Yu, Wei, Yang, Yi, Wang, Jiajia, Nie, Min, Jiang, Yan, Li, Mei, Xia, Weibo, Xing, Xiaoping, Wang, Ou |
| المصدر: |
Journal of Clinical Endocrinology & Metabolism; Jan2024, Vol. 109 Issue 1, p135-142, 8p |
| مصطلحات موضوعية: |
CANCELLOUS bone, WERMER syndrome, HYPERPARATHYROIDISM |
| مستخلص: |
Context The skeletal involvement of multiple endocrine neoplasia type 1-related primary hyperparathyroidism (MHPT) is not exactly the same as that of sporadic primary hyperparathyroidism (SHPT). Trabecular bone score (TBS) as a texture parameter has been reported to reflect trabecular bone damage. Objective This study aimed to compare the clinical characteristics, especially the skeletal involvement, between patients with MHPT and SHPT. Methods The clinical characteristics were retrospectively collected in 120 patients with MHPT and compared with 360 patients with SHPT in the same period. Dual-energy X-ray absorptiometry were conducted in some patients with MHPT, in whom bone mineral density (BMD) and calculated TBS derived from lumbar spine dual-energy X-ray absorptiometry images were compared with those of patients with SHPT. Results Although the duration of disease in the MHPT group was longer, the age at hospital visit was significantly lower than that in the SHPT group (43.5 [interquartile range, 31.5-52.0] vs 52.0 [interquartile range, 40.5-61.0], P <.001). The proportion of skeletal involvement in the MHPT group was significantly lower. However, in the subgroup of MHPT cases (n = 86) with data of BMD, there was no significant difference in skeletal involvement from SHPT cases matched for gender and age. Although the BMD and TBS in the lumbar spines of patients with MHPT were lower than those of patients with SHPT (BMD: 0.91 ± 0.18 g/cm2 vs 1.01 ± 0.17 g/cm2; TBS: 1.22 ± 0.14 vs 1.29 ± 0.11, P <.001). According to TBS, among 34 patients with MHPT with normal BMD, 15 patients had bone microstructure damage. Conclusion The cancellous bone microarchitecture was more severely damaged in patients with MHPT according to TBS, which suggested that TBS could be a sensitive supplemental index in addition to BMD to identify bone-involvement risk in patients with MHPT. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
