التفاصيل البيبلوغرافية
| العنوان: |
Utilising clinical parameters to improve the selection of nerve biopsy candidates. |
| المؤلفون: |
Kopanidis, Paul, Baskozos, Georgios, Byrne, Elizabeth, Hofer, Monika, Themistocleous, Andreas C., Rinaldi, Simon, Bennett, David L. |
| المصدر: |
Internal Medicine Journal; Dec2023, Vol. 53 Issue 12, p2224-2230, 7p |
| مصطلحات موضوعية: |
CEREBROSPINAL fluid examination, PERIPHERAL neuropathy diagnosis, DISEASE progression, BIOPSY, PERIPHERAL neuropathy, NEUROPHYSIOLOGY, PAIN, PATIENT selection, RETROSPECTIVE studies, EXANTHEMA, QUALITY assurance, DESCRIPTIVE statistics, SYMPTOMS, VASCULITIS, LONGITUDINAL method |
| مستخلص: |
Background: Peripheral nerve biopsy is a valuable final diagnostic tool; however, histopathological results can be non‐diagnostic. Aims: We aim to identify quality improvement measures by evaluating the pre‐biopsy assessment and diagnostic yield of specific histopathological diagnosis. Methods: This was a retrospective study based on 10 years of experience with peripheral nerve biopsies at a single centre. Clinical data were obtained regarding pre‐biopsy history, examination, serum and cerebrospinal fluid (CSF) investigations, neurophysiology and peripheral nerve imaging. Based upon a histopathological outcome, patients were grouped into vasculitis, granulomatous and infiltrative (diagnostic) group, or a comparison group of non‐specific axonal neuropathy and normal (non‐specific/normal) group. Results: From a cohort of 64 patients, 21 (32.8%) were included in the diagnostic group and 30 (46.9%) in the non‐specific/normal group. Clinical parameters associated with the diagnostic group were shorter history (mean 10.2 months vs 38.1), stepwise progression (81% vs 20%), neuropathic pain (85.7% vs 56.7%), vasculitic rash (23.8% vs 0%), mononeuritis multiplex (57.1% vs 10%), asymmetry (90.5% vs 60%), raised white cell count (47.6% vs 16.7%), myeloperoxidase antibody (19.1% vs 0%) and abnormal peripheral nerve imaging (33.3% vs 10%). Conclusion: Selection of patients undergoing nerve biopsy requires careful consideration of clinical parameters, including peripheral nerve imaging. Several quality improvement measures are proposed to improve yield of clinically actionable information from nerve biopsy. [ABSTRACT FROM AUTHOR] |
|
Copyright of Internal Medicine Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
