التفاصيل البيبلوغرافية
| العنوان: |
Cardiac morbidity and the cause of death in elderly patients with prostate cancer and incidental cardiac uptake on bone scintigraphy. |
| المؤلفون: |
Juntunen, Eero, Suomalainen, Olli, Mätzke, Sorjo, Heliö, Tiina, Loimaala, Antti, Uusitalo, Valtteri |
| المصدر: |
Clinical Physiology & Functional Imaging; Jan2024, Vol. 44 Issue 1, p49-55, 7p |
| مصطلحات موضوعية: |
RADIONUCLIDE imaging, PROSTATE cancer patients, OLDER patients, HEART failure, CARDIAC amyloidosis, CAUSES of death, CARDIOVASCULAR disease related mortality |
| مصطلحات جغرافية: |
FINLAND |
| مستخلص: |
Cardiac transthyretin amyloidosis (ATTR) is a possible incidental finding on bone scintigraphy imaged due to prostate cancer. We investigated its significance in 1426 elderly prostate cancer patients (>70 years) who underwent bone scintigraphy in three nuclear medicine departments in Finland. Patients with Perugini grade two or three uptakes were considered positive for cardiac uptake. Heart failure diagnoses and pacemaker implantations were collected from the hospital's records. Mortality data were gathered from the Finnish national statistical service (Statistics Finland). The Median follow‐up time was 4 years (interquartile range: 2−5 years). Cardiac uptake was detected in 37 individuals (2.6%), and it was associated with an elevated risk of both overall and cardiovascular death in univariable analysis. However, cardiac uptake did not predict overall mortality in the multivariable analysis when adjusted to age, bone metastases or the diagnosis of heart failure (p > 0.05). The risk of heart failure was higher in patients with cardiac uptake (47% vs. 15%, p < 0.001), while the risk of pacemaker implantations was not elevated (5% vs. 5%, p = 0.89). In conclusion, cardiac uptake on bone scintigraphy imaged due to prostate cancer is associated with an elevated risk of heart failure and both overall and cardiovascular death. However, cardiac uptake was not independently associated with overall mortality when adjusted to age, bone metastasis or heart failure. Therefore, they are essential to consider when incidental cardiac uptake is detected on bone scintigraphy. The need for pacemaker implantation was not elevated in patients with cardiac uptake. [ABSTRACT FROM AUTHOR] |
|
Copyright of Clinical Physiology & Functional Imaging is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
