التفاصيل البيبلوغرافية
| العنوان: |
Limited Benefit of Postexposure Prophylaxis With VSV-EBOV in Ebola Virus–Infected Rhesus Macaques. |
| المؤلفون: |
Bushmaker, Trenton, Feldmann, Friederike, Lovaglio, Jamie, Saturday, Greg, Griffin, Amanda J, O'Donnell, Kyle L, Strong, James E, Sprecher, Armand, Kobinger, Gary, Geisbert, Thomas W, Marzi, Andrea, Feldmann, Heinz |
| المصدر: |
Journal of Infectious Diseases; 2023 Supplement, Vol. 228, pS721-S729, 9p |
| مصطلحات موضوعية: |
RHESUS monkeys, VESICULAR stomatitis, PREVENTIVE medicine, DISEASE outbreaks, DISEASE progression |
| مستخلص: |
Vesicular stomatitis virus–Ebola virus (VSV-EBOV) vaccine has been successfully used in ring vaccination approaches during EBOV disease outbreaks demonstrating its general benefit in short-term prophylactic vaccination, but actual proof of its benefit in true postexposure prophylaxis (PEP) for humans is missing. Animal studies have indicated PEP efficacy when VSV-EBOV was used within hours of lethal EBOV challenge. Here, we used a lower EBOV challenge dose and a combined intravenous and intramuscular VSV-EBOV administration to improve PEP efficacy in the rhesus macaque model. VSV-EBOV treatment 1 hour after EBOV challenge resulted in delayed disease progression but little benefit in outcome. Thus, we could not confirm previous results indicating questionable benefit of VSV-EBOV for EBOV PEP in a nonhuman primate model. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
