التفاصيل البيبلوغرافية
| العنوان: |
The Clinical and Genetic Characteristics of Streptococcus agalactiae Meningitis in Neonates. |
| المؤلفون: |
Hsu, Jen-Fu, Lu, Jang-Jih, Chu, Shih-Ming, Lee, Wei-Ju, Huang, Hsuan-Rong, Chiang, Ming-Chou, Yang, Peng-Hong, Tsai, Ming-Horng |
| المصدر: |
International Journal of Molecular Sciences; Oct2023, Vol. 24 Issue 20, p15387, 12p |
| مصطلحات موضوعية: |
STREPTOCOCCUS agalactiae, NEWBORN infants, MENINGITIS, BACTERIAL meningitis, NUCLEOTIDE sequencing |
| مصطلحات جغرافية: |
TAIWAN |
| مستخلص: |
Streptococcus agalactiae (Group B Streptococcus, GBS) is an important pathogen of bacterial meningitis in neonates. We aimed to investigate the clinical and genetic characteristics of neonatal GBS meningitis. All neonates with GBS meningitis at a tertiary level medical center in Taiwan between 2003 and 2020 were analyzed. Capsule serotyping, multilocus sequence typing, antimicrobial resistance, and whole-genome sequencing (WGS) were performed on the GBS isolates. We identified 48 neonates with GBS meningitis and 140 neonates with GBS sepsis. Neonates with GBS meningitis had significantly more severe clinical symptoms; thirty-seven neonates (77.8%) had neurological complications; seven (14.6%) neonates died; and 17 (41.5%) survivors had neurological sequelae at discharge. The most common serotypes that caused meningitis in neonates were type III (68.8%), Ia (20.8%), and Ib (8.3%). Sequence type (ST) is highly correlated with serotypes, and ST17/III GBS accounted for more than half of GBS meningitis cases (56.3%, n = 27), followed by ST19/Ia, ST23/Ia, and ST12/Ib. All GBS isolates were sensitive to ampicillin, but a high resistance rates of 72.3% and 70.7% to erythromycin and clindamycin, respectively, were noted in the cohort. The virulence and pilus genes varied greatly between different GBS serotypes. WGS analyses showed that the presence of PezT; BspC; and ICESag37 was likely associated with the occurrence of meningitis and was documented in 60.4%, 77.1%, and 52.1% of the GBS isolates that caused neonatal meningitis. We concluded that GBS meningitis can cause serious morbidity in neonates. Further experimental models are warranted to investigate the clinical and genetic relevance of GBS meningitis. Specific GBS strains that likely cause meningitis requires further investigation and clinical attention. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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