التفاصيل البيبلوغرافية
| العنوان: |
Recurrent meningococcal infections associated with a functional deficiency of the C8 component of human complement. |
| المؤلفون: |
Matthews, N., Stark, J. M., Harper, P. S., Doran, J., Jones, D. M. |
| المصدر: |
Clinical & Experimental Immunology; Mar1980, Vol. 39 Issue 3, p53-59, 7p |
| مصطلحات موضوعية: |
BLOOD plasma, SERUM, EPITOPES, ANTIGEN-antibody reactions, PATIENTS, PHAGOCYTOSIS, INFECTION |
| مستخلص: |
A patient is described who had a functional deficiency of the C8 complement component. Ills serum contained abnormal C8 which lacked some of the antigenic determinants of normal CM. The defect was associated with recurrent meningococcal infections due at different times to at least two strains. The patient's serum contained antibodies to meningococcl and could induce phagocytosis and intracellular killing of the cocci by polymorphs. However, the serum was bactericidal only after the addition of C8-containing serum. As the patient did not give a history of susceptibility to other pyogenic organisms and has normal polvmorph function, the circumstances of meningococcal infection must he unusual in that the plasma bactericidal activity critically determines the outcome: it may he that if large numbers of meningococci are not killed in the plasma, the polymorphs are overwhelmed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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