التفاصيل البيبلوغرافية
| العنوان: |
Incidence and prevalence of generalized pustular psoriasis in multiethnic Johor Bahru, Malaysia: a population-based cohort study using routinely captured electronic health records in the Teleprimary Care (TPC®) clinical information system from 2010 to 2020 |
| المؤلفون: |
Choon, Siew Eng, Wright, Alison K, Griffiths, Christopher E M, Wong, Kit Wan, Tey, Kwee Eng, Lim, Yee Ting, Chua, Keow Yin, Ashcroft, Darren M |
| المصدر: |
British Journal of Dermatology; Oct2023, Vol. 189 Issue 4, p410-418, 9p |
| مصطلحات موضوعية: |
ELECTRONIC health records, INFORMATION storage & retrieval systems, MALAYSIANS, COHORT analysis, PSORIASIS |
| مصطلحات جغرافية: |
JOHOR Baharu (Johor, Malaysia), SOUTHEAST Asia |
| مستخلص: |
Background There is limited understanding of the epidemiology of generalized pustular psoriasis (GPP) internationally, with no population-based estimates of GPP in South East Asia. Objectives To determine the incidence and prevalence of GPP in the Malaysian population and characterize its flares and trigger factors. Methods We conducted a population-based cohort study using the Teleprimary Care database between January 2010 and December 2020. We identified 230 dermatologist-confirmed GPP cases using International Classification of Diseases, 10th revision, diagnostic codes. Annual prevalence and incidence rates were stratified by age, sex and ethnicity. We compared data regarding flares and trigger factors for patients with GPP who had associated psoriasis vulgaris (PV) with those who did not have associated PV. Results The prevalence of GPP was 198 per million (267 women, 127 men) and incidence was 27.2 per million person-years [95% confidence interval (CI) 22.8–31.6]; 35.3 (28.4–42.2) per million person-years for women and 18.3 (13.1–23.5) per million person-years for men. Rates were higher in Chinese individuals [prevalence 271 per million; incidence 41.6 per million person-years (28.9–54.3)] than in the Malay population [prevalence 186; incidence 24.6 (19.4–29.7)] or the Indian ethnic group [prevalence 179; incidence 25.0 (13.8–36.3)]. Annual prevalence was consistently higher in women than in men and highest among the Chinese population, followed by the Indian and Malay populations. Overall, 67% of patients with GPP had associated PV. The prevalence and incidence of GPP without PV were lower than GPP with PV at 66 vs. 132 per million and 19.3 (95% CI 15.6–23.0) vs. 8.0 (95% CI 5.6–10.3) per million person-years, respectively. The mean age at GPP onset was 42.7 years (SD 18.4). A bimodal trend in the age of GPP onset was observed, with first and second peaks at age 20–29 years and age 50–59 years, respectively. Disease onset was significantly earlier in patients with GPP without PV than in those with PV [mean age 37.5 years (SD 20.7) vs. 44.9 years (SD 17.0), P = 0.026]. Flares occurred more frequently in patients without PV than in those with PV [mean number of flares per patient per year was 1.35 (SD 0.77) vs. 1.25 (SD 0.58), P = 0.039]. Common triggers of flares in patients with GPP who did not have PV were infections, pregnancy, menstruation and stress, whereas withdrawal of therapy, particularly systemic corticosteroids, was a more frequent trigger in patients with GPP who also had PV. Conclusions Our findings contribute to the global mapping of GPP, which will help inform the management of this rare condition. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
