التفاصيل البيبلوغرافية
| العنوان: |
烟酰胺经调控 p38MAPK 信号通路对高血压脑出血大鼠的 脑保护作用机制分析. (Chinese) |
| العنوان البديل: |
Mechanism Analysis of the Protective Effect of Niacinamide on Hypertensive cerebral Hemorrhage in Rats by Regulating p38MAPK Signaling Pathway. (English) |
| المؤلفون: |
董西朝, 王林林, 张 亮, 袁致海, 高文文 |
| المصدر: |
Progress in Modern Biomedicine; 2023, Vol. 23 Issue 18, p3431-3444, 6p |
| مصطلحات موضوعية: |
CEREBRAL hemorrhage, HYDROCEPHALUS, NICOTINAMIDE, BRAIN injuries, CELLULAR signal transduction |
| الملخص (بالإنجليزية): |
Objective: To investigate the protective effect of niacinamide on hypertensive cerebral hemorrhage in rats by regulating p38MAPK signaling pathway. Methods: 48 SD rats were selected, 12 were randomly selected as sham operation group, and the remaining 36 rats underwent hypertensive intracerebral hemorrhage modeling. The volume of hematoma, the ratio of left twist, the changes of nerve function, the expression of p-p38MAPK, p38MAPK protein, the contents of niacinamide adenine dinucleotide, apoptosis-inducing factors and the water content of brain tissue were compared between the four groups. Results: Compared with the model group, the hematoma volume significantly decreased in the nimodipine and nicotinamide groups; compared with the nicotinamide group (P<0.05); in the nicotinamide and nimodipine group, the hematoma volume significantly increased in the model group (P<0.05). Compared with model group, the ratio of left twisting, p-p38MAPK/p38MAPK and nicotinamide adenine dinucleotides in sham operation group, nimodipine group and niacinamide group were significantly higher, while the contents of water content and apoptosis-inducing factors in brain tissue were significantly lower. Compared with niacinamide group, the ratio of left twisting, p-p38MAPK/p38MAPK and niacinamide adenine dinucleotide in nimodipine group and sham operation group were significantly higher, and the contents of water content and apoptosis-inducing factors in brain tissue were significantly lower. Compared with Nimodipine group, the ratio of left twist, P-P38MAPk /p38MAPK and niacinamide adenine dinucleotide in sham operation group were significantly higher, and the contents of water content and apoptosis-inducing factor in brain tissue were significantly lower (P<0.05). Conlusion: In hypertensive intracerebral hemorrhage rats, P38MAPK-mediated apoptosis pathway can aggravate the brain injury, and niacinamide can reduce the brain injury after hypertensive intracerebral hemorrhage by inhibiting p38MAPK signaling pathway. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
目的：探讨烟酰胺经调控 p38MAPK 信号通路对高血压脑出血大鼠的脑保护作用机制。方法：选择 48 只 SD 大鼠，随机选择 12 只作为假手术组，其余 36 只进行高血压脑出血造模，对比 4 组大鼠的血肿体积、左扭转比率、神经功能变化、出血脑组织 p-p38MAPK、p38MAPK 蛋白表达、烟酰胺腺嘌呤二核苷酸、凋亡诱导因子含量及脑组织含水量。结果：与模型组相比，尼莫地平 组、烟酰胺组的血肿体积明显缩小；与烟酰胺组相比，尼莫地平组的血肿体积明显缩小（P<0.05）；与干预前相比，干预后烟酰胺组、 尼莫地平组的血肿体积明显缩小，模型组的血肿体积明显增多（P<0.05）。与模型组相比，假手术组、尼莫地平组、烟酰胺组的向左 扭转比率、p-p38MAPK/p38MAPK、烟酰胺腺嘌呤二核苷酸明显较高，脑组织含水量、凋亡诱导因子含量明显较低；与烟酰胺组相 比，尼莫地平组、假手术组的左扭转比率、p-p38MAPK/p38MAPK、烟酰胺腺嘌呤二核苷酸明显较高，脑组织含水量、凋亡诱导因子 含量明显较低；与尼莫地平组相比，假手术组的左扭转比率、p-p38MAPK/p38MAPK、烟酰胺腺嘌呤二核苷酸明显较高，脑组织含 水量、凋亡诱导因子含量明显较低（P<0.05）。结论：在高血压脑出血大鼠中，p38MAPK 介导的细胞凋亡途径会加剧高血压脑出血 的脑损伤，烟酰胺会经过抑制 p38MAPK 信号通路减轻高血压脑出血后的脑损伤。 [ABSTRACT FROM AUTHOR] |
|
Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
