التفاصيل البيبلوغرافية
| العنوان: |
Survey of Pancreatic Enzyme Replacement Therapy Dosing Experiences in Adults with Exocrine Pancreatic Insufficiency. |
| المؤلفون: |
Lewis, Dana M., Shahid, Arsalan |
| المصدر: |
Healthcare (2227-9032); Aug2023, Vol. 11 Issue 16, p2316, 10p |
| مصطلحات موضوعية: |
AGE distribution, EXOCRINE pancreatic insufficiency, PROTEOLYTIC enzymes, ENZYMES, DISEASE duration, DESCRIPTIVE statistics, DOSE-effect relationship in pharmacology |
| مصطلحات جغرافية: |
NORTH America |
| مستخلص: |
Objectives: Pancreatic enzyme replacement therapy (PERT) is essential for treating exocrine pancreatic insufficiency (EPI), a condition where the pancreas does not produce adequate enzymes for digestion. This study delves into the real-world experiences of individuals with EPI regarding their PERT usage. Methods: A study was executed using a tailored survey targeting individuals with EPI. Quantitative data analysis assessed factors such as age, duration of EPI, elastase levels, choice of PERT, perceived effectiveness of titration, and the time taken for effective titration. Results: The study comprised 111 participants, predominantly female (93%) and hailing from North America (79%). Of these, 36.7% had been diagnosed with EPI for 3 or more years. A significant 72% felt they were not consistently consuming adequate enzymes, with only 22% believing their intake was sufficient. There were 44 participants (42%) still in the process of adjusting their enzyme doses. In contrast, 17 participants (16%) took a few weeks, 21 (20%) a few months, 11 (10%) over six months, 10 (9%) more than a year, and 3 (3%) several years for dose adjustment. Regarding enzyme titration advice, 30 participants (29%) received vague guidance, while 22 (21%) found the advice beneficial. Conclusions: This study underscores the pressing need for enhanced PERT dosing guidance. The insights gleaned spotlight the prevalent undertreatment across the entire EPI demographic, including in those with lesser-studied co-conditions. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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