التفاصيل البيبلوغرافية
| العنوان: |
Impact of repeat revascularization within 5 years on 10-year mortality after percutaneous or surgical revascularization. |
| المؤلفون: |
Wang, Rutao, Lunardi, Mattia, Hara, Hironori, Gao, Chao, Ono, Masafumi, Davierwala, Piroze M., Holmes, David R., Mohr, Friedrich W., Curzen, Nick, Burzotta, Francesco, van Geuns, Robert-Jan, Kappetein, Arie Pieter, Head, Stuart J., Thuijs, Daniel J. F. M., Tao, Ling, Garg, Scot, Onuma, Yoshinobu, Wijns, William, Serruys, Patrick W. |
| المصدر: |
Clinical Research in Cardiology; Sep2023, Vol. 112 Issue 9, p1302-1311, 10p |
| مستخلص: |
Background: The SYNTAX trial demonstrated negative impact of repeat revascularization (RR) on 5-year outcomes following PCI/CABG in patients with three-vessel(3VD) and/or left main coronary artery disease(LMCAD). We aimed to investigate the impact of RR within 5 years, on 10-year mortality in patients with 3VD and/or LMCAD after PCI/CABG. Methods: The SYNTAXES study evaluated the vital status out to 10 years of patients with 3VD and/or LMCAD. Patients were stratified by RR within 5 years and randomized treatment. The association between RR within 5 years and 10-year mortality was assessed. Results: A total of 330 out of 1800 patients (18.3%) underwent RR within 5 years. RR occurred more frequently after initial PCI than after initial CABG (25.9% vs. 13.7%, p < 0.001). Overall, 10-year mortality was comparable between patients undergoing RR and those not (28.2% vs. 26.1%, adjusted HR: 1.17, 95%CI 0.93–1.48, p = 0.187). In the PCI arm, RR was associated with a trend toward higher 10-year mortality (adjusted HR: 1.29, 95%CI 0.97–1.72, p = 0.075), while in the CABG arm, the trend was opposite (adjusted HR: 0.74, 95%CI 0.46–1.20, p = 0.219). Among patients requiring RR, those who underwent PCI as initial revascularization had a higher risk of 10-year mortality compared to initial CABG (33.5% vs. 17.6%, adjusted HR: 2.09, 95%CI 1.21–3.61, p = 0.008). Conclusion: In the SYNTAXES study, RR within 5 years had no impact on 10-year all-cause death in the population overall. Among patients requiring any repeat procedures, 10-year mortality was higher after initial treatment with PCI than after CABG. These exploratory findings should be investigated with larger populations in future studies. Trial registration: URL: https://www.clinicaltrials.govTest; SYNTAXES Unique identifier: NCT03417050. URL: https://www.clinicaltrials.govTest; SYNTAX Unique identifier: NCT00114972. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
