التفاصيل البيبلوغرافية
| العنوان: |
OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study. |
| المؤلفون: |
Baldanzi, Gabriel, Sayols-Baixeras, Sergi, Theorell-Haglöw, Jenny, Dekkers, Koen F., Hammar, Ulf, Nguyen, Diem, Lin, Yi-Ting, Ahmad, Shafqat, Holm, Jacob Bak, Nielsen, Henrik Bjørn, Brunkwall, Louise, Benedict, Christian, Cedernaes, Jonathan, Koskiniemi, Sanna, Phillipson, Mia, Lind, Lars, Sundström, Johan, Bergström, Göran, Engström, Gunnar, Smith, J. Gustav |
| المصدر: |
CHEST; Aug2023, Vol. 164 Issue 2, p503-516, 14p |
| مصطلحات موضوعية: |
GUT microbiome, HUMAN microbiota, FECAL microbiota transplantation, FECES, RESPIRATORY obstructions |
| مستخلص: |
OSA is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent upper airway obstruction and hypoxia, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition, and subsequent transplantation of fecal matter to other animals induced changes in BP and glucose metabolism. Does OSA in adults associate with the composition and functional potential of the human gut microbiota? We used respiratory polygraphy data from up to 3,570 individuals 50 to 64 years of age from the population-based Swedish Cardiopulmonary bioimage Study combined with deep shotgun metagenomics of fecal samples to identify cross-sectional associations between three OSA parameters covering apneas and hypopneas, cumulative sleep time in hypoxia, and number of oxygen desaturation events with gut microbiota composition. Data collection about potential confounders was based on questionnaires, onsite anthropometric measurements, plasma metabolomics, and linkage with the Swedish Prescribed Drug Register. We found that all three OSA parameters were associated with lower diversity of species in the gut. Furthermore, in multivariable-adjusted analysis, the OSA-related hypoxia parameters were associated with the relative abundance of 128 gut bacterial species, including higher abundance of Blautia obeum and Collinsella aerofaciens. The latter species was also independently associated with increased systolic BP. Furthermore, the cumulative time in hypoxia during sleep was associated with the abundance of genes involved in nine gut microbiota metabolic pathways, including propionate production from lactate. Finally, we observed two heterogeneous sets of plasma metabolites with opposite association with species positively and negatively associated with hypoxia parameters, respectively. OSA-related hypoxia, but not the number of apneas/hypopneas, is associated with specific gut microbiota species and functions. Our findings lay the foundation for future research on the gut microbiota-mediated health effects of OSA. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
