التفاصيل البيبلوغرافية
| العنوان: |
Formulation and Characterization of Electrospun Nanofibers for Melatonin Ocular Delivery. |
| المؤلفون: |
Romeo, Alessia, Kazsoki, Adrienn, Omer, Safaa, Pinke, Balázs, Mészáros, László, Musumeci, Teresa, Zelkó, Romána |
| المصدر: |
Pharmaceutics; Apr2023, Vol. 15 Issue 4, p1296, 17p |
| مصطلحات موضوعية: |
EYE drops, SCANNING electron microscopy, MELATONIN, LACTIC acid, NANOFIBERS |
| مستخلص: |
The poor ocular bioavailability of melatonin (MEL) limits the therapeutic action the molecule could exert in the treatment of ocular diseases. To date, no study has explored the use of nanofiber-based inserts to prolong ocular surface contact time and improve MEL delivery. Here, the electrospinning technique was proposed to prepare poly (vinyl alcohol) (PVA) and poly (lactic acid) (PLA) nanofiber inserts. Both nanofibers were produced with different concentrations of MEL and with or without the addition of Tween® 80. Nanofibers morphology was evaluated by scanning electron microscopy. Thermal and spectroscopic analyses were performed to characterize the state of MEL in the scaffolds. MEL release profiles were observed under simulated physiological conditions (pH 7.4, 37 °C). The swelling behavior was evaluated by a gravimetric method. The results confirmed that submicron-sized nanofibrous structures were obtained with MEL in the amorphous state. Different MEL release rates were achieved depending on the nature of the polymer. Fast (20 min) and complete release was observed for the PVA-based samples, unlike the PLA polymer, which provided slow and controlled MEL release. The addition of Tween® 80 affected the swelling properties of the fibrous structures. Overall, the results suggest that membranes could be an attractive vehicle as a potential alternative to liquid formulations for ocular administration of MEL. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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