التفاصيل البيبلوغرافية
| العنوان: |
Effects of Fragment ACTH15-18 and Its Analog ACTH15-18Pro-Gly-Pro on the Sequelae of Acute Stress. |
| المؤلفون: |
Manchenko, D. M., Glazova, N. Yu., Sebentsova, E. A., Andreeva, L. A., Dolotov, O. V., Kamensky, A. A., Myasoedov, N. F., Levitskaya, N. G. |
| المصدر: |
Neuroscience & Behavioral Physiology; Jan2023, Vol. 53 Issue 1, p132-141, 10p |
| مصطلحات موضوعية: |
LABORATORY rats, PEPTIDES, ADRENOCORTICOTROPIC hormone, DISEASE complications, CORTICOSTERONE |
| مستخلص: |
Tetrapeptide KKRR, corresponding to the ACTH15-18 sequence, is the shortest fragment with high-affinity binding with the ACTH receptor; it does not activate this receptor and prevents the whole hormone molecule from binding to it, and thus exhibits the properties of an ACTH receptor antagonist. The aim of the present work was to study the effects of peptide ACTH15-18 (KKRR) and its analog ACTH15-18PGP on behavior in Wistar rats in normal conditions and after acute stress produced by inescapable electrical foot shock. The peptides studied here did not affect the anxiety levels in white rats in normal conditions. Prior administration of ACTH15-18 (250 μg/kg) and its analog ACTH15-18PGP (50 and 250 μg/kg) decreased anxiety and corticosterone release in rats which had received a acute electrical foot shock stress. The extent and duration of the anti-stress effects of ACTH15-18PGP were significantly greater than the extent and duration of the effects of its natural prototype. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
