التفاصيل البيبلوغرافية
| العنوان: |
Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children: A Mediation Analysis Using the TEDDY Cohort. |
| المؤلفون: |
Andrén Aronsson, Carin, Tamura, Roy, Vehik, Kendra, Uusitalo, Ulla, Yang, Jimin, Haller, Michael J., Toppari, Jorma, Hagopian, William, McIndoe, Richard A., Rewers, Marian J., Ziegler, Anette-G., Akolkar, Beena, Krischer, Jeffrey P., Norris, Jill M., Virtanen, Suvi M., Elding Larsson, Helena |
| المصدر: |
Pediatric Diabetes; 2/17/2023, p1-11, 11p |
| مصطلحات موضوعية: |
ENERGY density, CONFIDENCE intervals, FOOD consumption, ANTHROPOMETRY, TYPE 1 diabetes, NUTRITIONAL requirements, ISLANDS of Langerhans, RISK assessment, DESCRIPTIVE statistics, FACTOR analysis, RESEARCH funding, BODY mass index, PROPORTIONAL hazards models, DISEASE risk factors, CHILDREN |
| مصطلحات جغرافية: |
UNITED States, SWEDEN, FINLAND, GERMANY |
| مستخلص: |
Background/Objective. Growth and obesity have been associated with increased risk of islet autoimmunity (IA) and progression to type 1 diabetes. We aimed to estimate the effect of energy-yielding macronutrient intake on the development of IA through BMI. Research Design and Methods. Genetically at-risk children (n = 5,084) in Finland, Germany, Sweden, and the USA, who were autoantibody negative at 2 years of age, were followed to the age of 8 years, with anthropometric measurements and 3-day food records collected biannually. Of these, 495 (9.7%) children developed IA. Mediation analysis for time-varying covariates (BMI z-score) and exposure (energy intake) was conducted. Cox proportional hazard method was used in sensitivity analysis. Results. We found an indirect effect of total energy intake (estimates: indirect effect 0.13 [0.05, 0.21]) and energy from protein (estimates: indirect effect 0.06 [0.02, 0.11]), fat (estimates: indirect effect 0.03 [0.01, 0.05]), and carbohydrates (estimates: indirect effect 0.02 [0.00, 0.04]) (kcal/day) on the development of IA. A direct effect was found for protein, expressed both as kcal/day (estimates: direct effect 1.09 [0.35, 1.56]) and energy percentage (estimates: direct effect 72.8 [3.0, 98.0]) and the development of GAD autoantibodies (GADA). In the sensitivity analysis, energy from protein (kcal/day) was associated with increased risk for GADA, hazard ratio 1.24 (95% CI: 1.09, 1.53), p = 0.042. Conclusions. This study confirms that higher total energy intake is associated with higher BMI, which leads to higher risk of the development of IA. A diet with larger proportion of energy from protein has a direct effect on the development of GADA. [ABSTRACT FROM AUTHOR] |
|
Copyright of Pediatric Diabetes is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder